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Psalm 143

Psa. 143:4 KJV (With Strong’s)

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4
Therefore is my spirit
ruwach (Hebrew #7307)
wind; by resemblance breath, i.e. a sensible (or even violent) exhalation; figuratively, life, anger, unsubstantiality; by extension, a region of the sky; by resemblance spirit, but only of a rational being (including its expression and functions)
KJV usage: air, anger, blast, breath, X cool, courage, mind, X quarter, X side, spirit((-ual)), tempest, X vain, ((whirl-))wind(-y).
Pronounce: roo'-akh
Origin: from 7306
overwhelmed
`ataph (Hebrew #5848)
to shroud, i.e. clothe (whether transitive or reflex.); hence (from the idea of darkness) to languish
KJV usage: cover (over), fail, faint, feebler, hide self, be overwhelmed, swoon.
Pronounce: aw-taf'
Origin: a primitive root
within me; my heart
leb (Hebrew #3820)
the heart; also used (figuratively) very widely for the feelings, the will and even the intellect; likewise for the centre of anything
KJV usage: + care for, comfortably, consent, X considered, courag(-eous), friend(-ly), ((broken-), (hard-), (merry-), (stiff-), (stout-), double) heart((-ed)), X heed, X I, kindly, midst, mind(-ed), X regard((-ed)), X themselves, X unawares, understanding, X well, willingly, wisdom.
Pronounce: labe
Origin: a form of 3824
within
tavek (Hebrew #8432)
a bisection, i.e. (by implication) the centre
KJV usage: among(-st), X between, half, X (there- ,where-), in(-to), middle, mid(-night), midst (among), X out (of), X through, X with(-in).
Pronounce: taw'-vek
Origin: from an unused root meaning to sever
me is desolate
shamem (Hebrew #8074)
to stun (or intransitively, grow numb), i.e. devastate or (figuratively) stupefy (both usually in a passive sense)
KJV usage: make amazed, be astonied, (be an) astonish(-ment), (be, bring into, unto, lay, lie, make) desolate(-ion, places), be destitute, destroy (self), (lay, lie, make) waste, wonder.
Pronounce: shaw-mame'
Origin: a primitive root
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Ministry on This Verse

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is my spirit.
my heart.
 Hence they look to the Lord for a speedy answer to their supplications. Their spirit has been tried to the utmost. They acknowledge that if the Lord will not help all is hopeless and their end will be as those who go down to the pit (vs. 4-8). (Book 5. by B. Anstey)
 The inward effect is that his spirit is overwhelmed, and his heart desolate. (Psalms 143 by H. Smith)

J. N. Darby Translation

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And my spirit is overwhelmed within me; my heart within me is desolate.