defile (self), pollute (self), be (make, make self, pronounce) unclean, X utterly

Boyd’s Bible Dictionary:

A word which, with clean, was applied to personal and ceremonial conditions, as well as to the edibility of animals
The division of animals into clean and unclean existed before the Flood (Gen. 7:2). Uncleanness and the processes of purification are particularly described (Lev. 11-15; Num. 19). Unclean animals are specially mentioned (Lev. 11:9-31; Deut. 14:3-20).

Concise Bible Dictionary:

Ceremonial uncleanness had a large place in the Jewish ritual (Lev. 5:3). It demanded separation from the camp for a time, and in many cases an offering must be brought before there could be restoration. It is typical of the moral uncleanness that separates from communion with God and the assembly.

Strong’s Dictionary of Hebrew Words:

Transliteration:
tame’
Phonic:
taw-may’
Meaning:
a primitive root; to be foul, especially in a ceremial or moral sense (contaminated)
KJV Usage:
defile (self), pollute (self), be (make, make self, pronounce) unclean, X utterly