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Colossians 4

Col. 4:2 KJV (With Strong’s)

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proskartereo (Greek #4342)
to be earnest towards, i.e. (to a thing) to persevere, be constantly diligent, or (in a place) to attend assiduously all the exercises, or (to a person) to adhere closely to (as a servitor)
KJV usage: attend (give self) continually (upon), continue (in, instant in, with), wait on (continually).
Pronounce: pros-kar-ter-eh'-o
Origin: from 4314 and 2594
i in prayer
ho (Greek #3588)
the definite article; the (sometimes to be supplied, at others omitted, in English idiom)
KJV usage: the, this, that, one, he, she, it, etc.
Pronounce: ho
Origin: ἡ (hay), and the neuter τό (to) in all their inflections
proseuche (Greek #4335)
prayer (worship); by implication, an oratory (chapel)
KJV usage: X pray earnestly, prayer.
Pronounce: pros-yoo-khay'
Origin: from 4336
, and watch
gregoreuo (Greek #1127)
to keep awake, i.e. watch (literally or figuratively)
KJV usage: be vigilant, wake, (be) watch(-ful).
Pronounce: gray-gor-yoo'-o
Origin: from 1453
j in
en (Greek #1722)
"in," at, (up-)on, by, etc.
KJV usage: about, after, against, + almost, X altogether, among, X as, at, before, between, (here-)by (+ all means), for (... sake of), + give self wholly to, (here-)in(-to, -wardly), X mightily, (because) of, (up-)on, (open-)ly, X outwardly, one, X quickly, X shortly, (speedi-)ly, X that, X there(-in, -on), through(-out), (un-)to(-ward), under, when, where(-with), while, with(-in). Often used in compounds, with substantially the same import; rarely with verbs of motion, and then not to indicate direction, except (elliptically) by a separate (and different) preposition.
Pronounce: en
Origin: a primary preposition denoting (fixed) position (in place, time or state), and (by implication) instrumentality (medially or constructively), i.e. a relation of rest (intermediate between 1519 and 1537)
the same
autos (Greek #846)
the reflexive pronoun self, used (alone or in the comparative 1438) of the third person , and (with the proper personal pronoun) of the other persons
KJV usage: her, it(-self), one, the other, (mine) own, said, (self-), the) same, ((him-, my-, thy- )self, (your-)selves, she, that, their(-s), them(-selves), there(-at, - by, -in, -into, -of, -on, -with), they, (these) things, this (man), those, together, very, which. Compare 848.
Pronounce: ow-tos'
Origin: from the particle αὖ (perhaps akin to the base of 109 through the idea of a baffling wind) (backward)
with
en (Greek #1722)
"in," at, (up-)on, by, etc.
KJV usage: about, after, against, + almost, X altogether, among, X as, at, before, between, (here-)by (+ all means), for (... sake of), + give self wholly to, (here-)in(-to, -wardly), X mightily, (because) of, (up-)on, (open-)ly, X outwardly, one, X quickly, X shortly, (speedi-)ly, X that, X there(-in, -on), through(-out), (un-)to(-ward), under, when, where(-with), while, with(-in). Often used in compounds, with substantially the same import; rarely with verbs of motion, and then not to indicate direction, except (elliptically) by a separate (and different) preposition.
Pronounce: en
Origin: a primary preposition denoting (fixed) position (in place, time or state), and (by implication) instrumentality (medially or constructively), i.e. a relation of rest (intermediate between 1519 and 1537)
thanksgiving
eucharistia (Greek #2169)
gratitude; actively, grateful language (to God, as an act of worship)
KJV usage: thankfulness, (giving of) thanks(-giving).
Pronounce: yoo-khar-is-tee'-ah
Origin: from 2170
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Ministry on This Verse

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Col. 4:12• 12There saluteth you Epaphras, who [is] of you, a bondman of Jesus Christ, always striving for you in prayers, that ye may stand perfect and complete in all [the] will of God. (Col. 4:12)
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Col. 1:9• 9On this account we also, from the day that we heard, do not cease praying for you, and asking that ye might be filled with the full knowledge of his will in all wisdom and spiritual understanding; (Col. 1:9)
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1 Sam. 12:23• 23{i}Moreover, as for me, far be it from me that I should sin against Jehovah in ceasing to pray for you; and I will teach you the good and right way{/i}. (1 Sam. 12:23)
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Job 15:4• 4Yea, thou makest void the fear of God,{HR}And diminishest devotion before God. (Job 15:4)
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Job 27:8‑10• 8For what [is] the hope of the impure that he shall gain,{HR}When God shall draw out his soul?
9Doth God [El] hear his cry when trouble cometh on him?
10Doth he delight in the Almighty?{HR}Doth he call on God at all times?
(Job 27:8‑10)
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Psa. 55:16‑17• 16As for me, unto God will I call;{HR}And Jehovah will save me.
17Evening and morning and noon I will complain and moan;{HR}And he will hear my voice.
(Psa. 55:16‑17)
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Psa. 109:4• 4For my love they are mine adversaries,{HR}And I [am for] prayer. (Psa. 109:4)
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Luke 18:1• 1And he spoke also a parable to them, to the purport that they should always pray, and not faint, (Luke 18:1)
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Rom. 12:12• 12in hope rejoicing; in tribulation enduring, in prayer persevering; (Rom. 12:12)
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Eph. 6:18• 18with all prayer and supplication praying in every season in [the] Spirit, and thereunto watching with all perseverance and supplication for all the saints, (Eph. 6:18)
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Phil. 4:6• 6Be anxious about nothing, but in everything by prayer and supplication with thanksgiving let your requests be made known unto God. (Phil. 4:6)
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1 Thess. 5:17‑18• 17pray unceasingly;
18in everything give thanks, for this [is] God's will in Christ Jesus toward you.
(1 Thess. 5:17‑18)
watch.
thanksgiving.
 We are in conflict with evil, which has a hold upon our own hearts if we are without the strength of God. We must therefore commune with God. We must watch therein with settled purpose of heart, not merely as an occasional thing: anyone can cry out when he is in need. (Colossians 4 by J.N. Darby)
 Neither completeness in Christ, nor joyful sense of heavenly relationship, nor heed to our own relations in this life, should weaken for an instant, but rather minister to an increased sense of the need and value of depending on God. (Colossians 4 by W. Kelly)
 Oftentimes we pray for something but give up….Persevering in prayer does not mean that we are to badger God regarding something we want, and to persist in asking for it until He gives it to us. (Christ Expressed in the Spread of the Truth in the World: Colossians 4:2-6 by B. Anstey)
 To “watch in the same” is to watch for the Lord’s answer to our prayer requests. This manifests faith. To do it “with thanksgiving” manifests confidence in the Lord. It is to say, “Whatever the Lord gives as an answer (be it ‘yes’ or ‘no’), I know that it will be the best for me. (Christ Expressed in the Spread of the Truth in the World: Colossians 4:2-6 by B. Anstey)

J. N. Darby Translation

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Persevere in prayer, watching in it with thanksgiving;

W. Kelly Translation

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Persevere in prayer, watching in it with thanksgiving;